Oxidative stress state in patients with atopic Eczema in Anbar Governorate
DOI:
https://doi.org/10.5281/zenodo.10308237Keywords:
atopic dermatitis/eczema, Superoxide dismutase, total antioxidant capacity, Oxidative stressAbstract
Atopic Eczema commonly known as atopic dermatitis (AD), is a form of inflammatory skin condition that impairs the skin barrier and its capacity to retain moisture, it is the most prevalent chronic skin condition and is inherited. Although AD can affect people of all ages, it most often first manifests in infancy and early childhood. (AD) a varied, complex chronic inflammatory skin condition, Atopic dermatitis is thought to arise for a variety of reasons, including genetic factors connected to filaggrin malfunction. Both its duration and its onset in maturity are possibilities, Patients are affected by the intense itching of the disease, which commonly results in skin injuries and major sleep problems, as well as the social shame attached to having a visible skin ailment. Through the activation of genes that code for proinflammatory cytokines, oxidative stress encourages tissue inflammation. Free radicals are then released when inflammatory cells are activated. Given AD's strong inflammatory underpinning, Since oxidative stress has been shown to have a major role in skin aging, it is likely that it contributes to the genesis of the illness. Researching the correlation between oxidative stressors including MDA, SOD, and T-AOC, as well as inflammation, is crucial in Alzheimer's disease. We enrolled 75 patients divided into (25 infants, 25 children, and 25 adults) with AD and 51 healthy controls divided into (17 infants, 17 children, and 17 adults ) individuals who did not have the disease and had no history of AD. We measure serum (Malondialdehyde MDA, Superoxide dismutase SOD, and Total antioxidant capacity T-AOC). Serum (MDA) levels were significantly increased in AD patients compared to controls, and Serum (SOD and T-AOC) levels were significantly decreased in AD patients compared to controls.
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