Gastroprotective effect of Iraqi dates Palm (Phoenix dactylifera L. Cv. "Barhi") dates and seeds extracts on ethanol-induced gastric ulcer in rats
DOI:
https://doi.org/10.5281/zenodo.10270297Keywords:
Famotidine, gastrin, glutathioneAbstract
Objective: The goal is to find effective treatments for gastric ulcers with minimal side effects. We used ethanol-induced gastric ulcer models in rats to examine the gastro-protective benefits of Iraqi dates palm (Phoenix dactylifera L. Cv. " Barhi ") Methods: Six groups of seven rats each were formed from 42 rats. Groups 1 (normal control) and 2 (negative control) were given 10 ml/kg of distilled water; group 3 (positive control) was given famotidine (20 mg/kg); groups 4 date palm fruit extract were given (8 ml/kg); groups 5 date palm seed extract were given (8 ml/kg); and groups 6 mixture of date palm fruit extract and date palm seed extract were given (8 ml/kg). On day 15, rats in all groups (except the normal control group) received an oral administration of 99.8% ethanol (5 ml/kg) to cause an acute ulcer. All animals were slaughtered after 1 hour, and their stomachs were removed for further analysis. Results: Date fruit, date seed, and a combination of aqueous extracts were efficient in reducing the severity of gastric ulceration and protecting against ethanol's negative effects on gastrin, glutathione, and gastric mucus. Conclusion: Date extracts have been hypothesized to have a gastroprotective effect due to their potential anti-oxidant properties.
References
Aihara, T., Nakamura, E., Amagase, K., Tomita, K., Fujishita, T., Furutani, K., & Okabe, S. (2003). Pharmacological control of gastric acid secretion for the treatment of acid-related peptic disease: past, present, and future. Pharmacology & Therapeutics, 98(1), 109–127.
Al-Alawi, R. A., Al-Mashiqri, J. H., Al-Nadabi, J. S. M., Al-Shihi, B. I., & Baqi, Y. (2017). Date palm tree (Phoenix dactylifera L.): natural products and therapeutic options. Frontiers in Plant Science, 8, 845.
Al-Farsi*, M. A., & Lee, C. Y. (2008). Nutritional and functional properties of dates: a review. Critical Reviews in Food Science and Nutrition, 48(10), 877–887.
Al-Farsi, M., Alasalvar, C., Morris, A., Baron, M., & Shahidi, F. (2005). Comparison of antioxidant activity, anthocyanins, carotenoids, and phenolics of three native fresh and sun-dried date (Phoenix dactylifera L.) varieties grown in Oman. Journal of Agricultural and Food Chemistry, 53(19), 7592–7599.
Al-Qarawi, A. A., Abdel-Rahman, H., Ali, B. H., Mousa, H. M., & El-Mougy, S. A. (2005). The ameliorative effect of dates (Phoenix dactylifera L.) on ethanol-induced gastric ulcer in rats. Journal of Ethnopharmacology, 98(3), 313–317.
Al-Qarawi, A. A., Abdel-Rahman, H., Mousa, H. M., Ali, B. H., & El-Mougy, S. A. (2008). Nephroprotective action of Phoenix dactylifera. in gentamicin-induced nephrotoxicity. Pharmaceutical Biology, 46(4), 227–230.
Al-Rehaily, A. J., Al-Howiriny, T. S., Al-Sohaibani, M. O., & Rafatullah, S. (2002). Gastroprotective effects of ‘Amla’Emblica officinalis on in vivo test models in rats. Phytomedicine, 9(6), 515–522.
Al-Yahya, M., Raish, M., AlSaid, M. S., Ahmad, A., Mothana, R. A., Al-Sohaibani, M., Al-Dosari, M. S., Parvez, M. K., & Rafatullah, S. (2016). ‘Ajwa’dates (Phoenix dactylifera L.) extract ameliorates isoproterenol-induced cardiomyopathy through downregulation of oxidative, inflammatory and apoptotic molecules in rodent model. Phytomedicine, 23(11), 1240–1248.
Behrman, S. W. (2005). Management of complicated peptic ulcer disease. Archives of Surgery, 140(2), 201–208.
Büyükokuroğlu, M. E., Taysi, S., Polat, F., & Göçer, F. (2002). Mechanism of the beneficial effects of dantrolene sodium on ethanol-induced acute gastric mucosal injury in rats. Pharmacological Research, 45(5), 421–425.
Chaira, N., Smaali, M. I., Martinez-Tomé, M., Mrabet, A., Murcia, M. A., & Ferchichi, A. (2009). Simple phenolic composition, flavonoid contents and antioxidant capacities in water-methanol extracts of Tunisian common date cultivars (Phoenix dactylifera L.). International Journal of Food Sciences and Nutrition, 60(sup7), 316–329.
da Silva, L. M., Allemand, A., Mendes, D. A. G. B., Dos Santos, A. C., André, E., de Souza, L. M., Cipriani, T. R., Dartora, N., Marques, M. C. A., & Baggio, C. H. (2013). Ethanolic extract of roots from Arctium lappa L. accelerates the healing of acetic acid-induced gastric ulcer in rats: Involvement of the antioxidant system. Food and Chemical Toxicology, 51, 179–187.
DeVault, K. R., & Talley, N. J. (2009). Insights into the future of gastric acid suppression. Nature Reviews Gastroenterology & Hepatology, 6(9), 524–532.
Fernández-López, J., Viuda-Martos, M., Sayas-Barberá, E., Navarro-Rodríguez de Vera, C., & Pérez-álvarez, J. Á. (2022). Biological, Nutritive, Functional and Healthy Potential of Date Palm Fruit (Phoenix dactylifera L.): Current Research and Future Prospects. Agronomy, 12(4). https://doi.org/10.3390/agronomy12040876
Ghnimi, S., Umer, S., Karim, A., & Kamal-Eldin, A. (2017). Date fruit (Phoenix dactylifera L.): An underutilized food seeking industrial valorization. NFS Journal, 6, 1–10. https://doi.org/10.1016/j.nfs.2016.12.001
Hirota, M., Inoue, M., Ando, Y., Hirayama, K., Morino, Y., Sakamoto, K., Mori, K., & Akagi, M. (1989). Inhibition of stress-induced gastric injury in the rat by glutathione. Gastroenterology, 97(4), 853–859.
Ibrahim, A. O. (2008). Date palm the tree of life. Arab Center for the Study of Arid Zones and Dry Lands. Damascus, Syria.
Jassim, S. A. A., & Naji, M. A. (2010). In vitro evaluation of the antiviral activity of an extract of date palm (Phoenix dactylifera L.) pits on a Pseudomonas phage. Evidence-Based Complementary and Alternative Medicine, 7(1), 57–62.
Kahraman, A., Erkasap, N., Köken, T., Serteser, M., Aktepe, F., & Erkasap, S. (2003). The antioxidative and antihistaminic properties of quercetin in ethanol-induced gastric lesions. Toxicology, 183(1–3), 133–142.
Kangwan, N., Park, J.-M., Kim, E.-H., & Hahm, K. B. (2014). Quality of healing of gastric ulcers: natural products beyond acid suppression. World Journal of Gastrointestinal Pathophysiology, 5(1), 40.
Karaoğlan, E. S., Albayrak, A., Kutlu, Z., & Bayır, Y. (2018). Gastroprotective and antioxidant effects of eremurus spectabilis bieb. Methanol extract and its isolated component isoorientin on indomethacin induced gastric ulcers in rats. Acta Cirurgica Brasileira, 33(7), 609–618. https://doi.org/10.1590/s0102-865020180070000006
Konturek, J. W., Hengst, K., Konturek, S. J., Sito, E., Stachura, J., & Domschke, W. (1998). Physiological role of cholecystokinin in gastroprotection in humans. The American Journal of Gastroenterology, 93(12), 2385–2390.
Konturek, S. J., Konturek, P. C., Pawlik, T., Sliwowski, Z., Ochmanski, W., & Hahn, E. G. (2004). DUODENAL MUCOSAL PROTECTION BY BICARBONATE. Journal of Physiology and Pharmacology, 55(2), 5–17.
Kovac, S., Anderson, G. J., & Baldwin, G. S. (2011). Gastrins, iron homeostasis and colorectal cancer. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1813(5), 889–895.
Kvietys, P. R., Twohig, B., Danzell, J., & Specian, R. D. (1990). Ethanol-induced injury to the rat gastric mucosa: Role of neutrophils and xanthine oxidase-derived radicals. Gastroenterology, 98(4), 909–920.
Liu, R., Hao, Y. T., Zhu, N., Liu, X. R., Kang, J. W., Mao, R. X., Hou, C., & Li, Y. (2020). The gastroprotective effect of small molecule oligopeptides isolated from walnut (Juglans regia l.) against ethanol-induced gastric mucosal injury in rats. Nutrients, 12(4). https://doi.org/10.3390/nu12041138
Maqsood, S., Adiamo, O., Ahmad, M., & Mudgil, P. (2020). Bioactive compounds from date fruit and seed as potential nutraceutical and functional food ingredients. Food Chemistry, 308, 125522.
Mard, S. A., Bahari, Z., Eshaghi, N., & Farbood, Y. (2008). Antiulcerogenic effect of Securigera securidaca L. seed extract on various experimental gastric ulcer models in rats. Pakistan Journal of Biological Sciences, 11(23), 2619.
Mercer, D. W., Cross, J. M., Smith, G. S., & Miller, T. A. (1997). Protective action of gastrin-17 against alcohol-induced gastric injury in the rat: role in mucosal defense. American Journal of Physiology-Gastrointestinal and Liver Physiology, 273(2), G365–G373.
Musa, M. A., Dibal, N. I., Chiroma, M. S., & Makena, W. (2017). Protective role of Phoenix dactylifera fruit against ethanol-induced gastric ulcer in Wistar rats. Annals of Research Hospital, 1(46), 1–7.
Orabi, S. H., & Shawky, S. M. (2014). Effect of date palm (Phoenix dactylifera) seeds extracts on hematological, biochemical parameters and some fertility indices in male rats. International Journal of Sciences: Basic and Applied Research, 17(1), 137–147.
Parra-Cid, T., Calvino-Fernández, M., & Gisbert, J. P. (2011). Helicobacter pylori and peptic ulcer—role of reactive oxygen species and apoptosis. Peptic Ulcer Disease, 9.
Pastore, A., Federici, G., Bertini, E., & Piemonte, F. (2003). Analysis of glutathione: implication in redox and detoxification. Clinica Chimica Acta, 333(1), 19–39.
Potterat, O. (1997). Antioxidants and free radical scavengers of natural origin. Current Organic Chemistry, 1(4), 415–440.
Pradeepkumar Singh, L., Kundu, P., Ganguly, K., Mishra, A., & Swarnakar, S. (2007). Novel role of famotidine in downregulation of matrix metalloproteinase-9 during protection of ethanol-induced acute gastric ulcer. Free Radical Biology and Medicine, 43(2), 289–299. https://doi.org/10.1016/j.freeradbiomed.2007.04.027
Raish, M., Ahmad, A., Ansari, M. A., Alkharfy, K. M., Aljenoobi, F. I., Jan, B. L., Al-Mohizea, A. M., Khan, A., & Ali, N. (2018). Momordica charantia polysaccharides ameliorate oxidative stress, inflammation, and apoptosis in ethanol-induced gastritis in mucosa through NF-kB signaling pathway inhibition. International Journal of Biological Macromolecules, 111, 193–199.
Ramakrishnan, K., & Salinas, R. C. (2007). Peptic ulcer disease. American Family Physician, 76(7), 1005–1012.
Reddy, V. P., Sudheshna, G., Afsar, S. K., Saran, S., Kumar, S. N., Ram, C. R., & Reddy, K. R. (2012). Evaluation of anti-ulcer activity of Citrullus colocynthis fruit against pylorus ligation induced ulcers in male wistar rats. Int J Pharm Pharm Sci, 4(2), 446–451.
Riezzo, G., Chiloiro, M., & Montanaro, S. (2001). Protective effect of amtolmetin guacyl versus placebo diclofenac and misoprostol in healthy volunteers evaluated as gastric electrical activity in alcohol-induced stomach damage. Digestive Diseases and Sciences, 46, 1797–1804.
Saeed AL-Wajeeh, N., Halabi, M. F., Hajrezaie, M., M. Dhiyaaldeen, S., Abdulaziz Bardi, D., M. Salama, S., Rouhollahi, E., Karimian, H., Abdolmalaki, R., & Azizan, A. H. S. (2016). The gastroprotective effect of vitex pubescens leaf extract against ethanol-provoked gastric mucosal damage in sprague-dawley rats. PLoS One, 11(9), e0157431.
Salga, M. S., Ali, H. M., Abdulla, M. A., & Abdelwahab, S. I. (2012). Gastroprotective activity and mechanism of novel dichlorido-zinc (II)-4-(2-(5-methoxybenzylideneamino) ethyl) piperazin-1-iumphenolate complex on ethanol-induced gastric ulceration. Chemico-Biological Interactions, 195(2), 144–153.
Simões, S., Lopes, R., Campos, M. C. D., Marruz, M. J., da Cruz, M. E. M., & Corvo, L. (2019). Animal models of acute gastric mucosal injury: Macroscopic and microscopic evaluation. Animal Models and Experimental Medicine, 2(2), 121–126.
Sistani Karampour, N., Arzi, A., Rezaie, A., Pashmforoosh, M., & Kordi, F. (2019). Gastroprotective effect of zingerone on ethanol-induced gastric ulcers in rats. Medicina, 55(3), 64.
Souli, I., Jemni, M., Rodríguez‐Verástegui, L. L., Chaira, N., Artés, F., & Ferchichi, A. (2018). Phenolic composition profiling of Tunisian 10 varieties of common dates (Phoenix dactylifera L.) at tamar stage using LC‐ESI‐MS and antioxidant activity. Journal of Food Biochemistry, 42(6), e12634.
Taha, A. S., Hudson, N., Hawkey, C. J., Swannell, A. J., Trye, P. N., Cottrell, J., Mann, S. G., Simon, T. J., Sturrock, R. D., & Russell, R. I. (1996). Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs. New England Journal of Medicine, 334(22), 1435–1439.
Terano, A., Hiraishi, H., Ota, S., Shiga, J., & Sugimoto, T. (1989). Role of superoxide and hydroxyl radicals in rat gastric mucosal injury induced by ethanol. Gastroenterologia Japonica, 24, 488–493.
Wu, X., Huang, Q., Xu, N., Cai, J., Luo, D., Zhang, Q., Su, Z., Gao, C., & Liu, Y. (2018). Antioxidative and anti-inflammatory effects of water extract of Acrostichum aureum Linn. against ethanol-induced gastric ulcer in rats. Evidence-Based Complementary and Alternative Medicine, 2018.
Zaid, A. (2010). The world date production: a challenging case study. Date Palm Research and Development Programme. United Nations Office for Project Services/UNOPS. Al Ain.
Zayachkivska, O. S., Konturek, S. J., Drozdowicz, D., Konturek, P. C., Brzozowski, T., & Ghegotsky, M. R. (2005). Gastroprotective effects of flavonoids in plant extracts. Journal of Physiology and Pharmacology. Supplement, 56(1), 219–231.
Zelickson, M. S., Bronder, C. M., Johnson, B. L., Camunas, J. A., Smith, D. E., Rawlinson, D., Von, S., Stone, H. H., & Taylor, S. M. (2011). Helicobacter pylori is not the predominant etiology for peptic ulcers requiring operation. The American Surgeon, 77(8), 1054–1060.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Journal of Wildlife and Biodiversity
This work is licensed under a Creative Commons Attribution 4.0 International License.
JWB applies the 