Synthesis, Characterization and Biological activity of mixed ligand Dimedon and Isatin with metal complex
DOI:
https://doi.org/10.5281/zenodo.10211625Keywords:
Mixed ligand complex, Dimedon, Isatin, Anti-microbialAbstract
New compounds of mixed ligand complex (Scheme 1) were synthesized by the reaction of metal ions Zn (II), Cd (II), Co (II), Mn (II), Ni (II) Cu (II) and Fe (II) with the Dimedon (L1) as a primary ligand and Isatin (L2) as a secondary ligand in a molar ratio of 1:1:1 and identified using several spectral analysis methods, where used UV-visible, CHNOS elemental analysis, FT-IR, molar conductivity, mass spectrum, magnetic susceptibility and additionally, Chloride content as a quantitative evaluation, according to the results obtained by analysis methods, we observed that all the synthesized complexes showed apparent stability, an octahedral structure is suggested for all the prepared complexes, anti-bacterial and anti-fungal activities of these metal complexes were evaluated against Escherichia Coli, Spuedomonas (Gram-negative bacteria), Bacillus sp., Staphylococcus aureus (Gram-positive bacteria) and Fuzarium, Aspergillus a fungal species. The samples of the cultivated complexes showed varying results from the inhibition zone, and a similar one showed its ineffectiveness in inhibiting the growth of bacteria or fungi according to the concentrations prepared.
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