Impact of IL-6-174G/C, IL-10-1082A/G Gene Polymorphisms on Toxoplasma gondii infections
DOI:
https://doi.org/10.5281/zenodo.10212098Keywords:
Toxoplasmosis, SNP, Cytokines, IL-6-174G/C, IL-10-1082A/G, TNF-α-308G/CAbstract
Toxoplasma gondii is one of the most common intrauterine infections worldwide and the major cause of perinatal morbidity and mortality. Aims: this study is to determine the genetic susceptibility of certain types of cytokine single nucleotide gene polymorphism to toxoplasmosis. Materials: study involved 40 females with confirmed seropositive toxoplasma gondii infection and 30 healthy females as control group. Single nucleotide gene polymorphisms of IL-16-174G/C, IL-10-1082A/G and TNF-α-308G/C were determined. Results: IL-6-174G/C results showed no relations between GG and the disease, the protective effect of GC genotype, and CC as risk factor with 3 folded effect OR:3.22. C allele as a risk for the infection. For IL-10-1082A/G genotypes, the wild and mutant homozygotes were associated with the disease with almost 1.5 folded effects, OR: 1.46 and 1.56 respectively. While the mutant heterozygote has protective effect against the disease, OR: 0.57. Conclusion: study found positive relation between the IL-6-174 CC genotype with 3 folded effects, and for IL-10-1082A/G the AA and AG were associated with the disease by 1.5 fold.
References
Rasyan, & Ray. (2004). Sherris Medical Microbiology (4 ed.). New York, USA: McGraw.
Nicolle, & Manceaux. (1909). Sur un protozoaire nouveau du gondi. Paris, France: C R Soc Biol.
Ayeh-Kumi, Opoku, A. G., Kwakye, N., Dayie, N., Asmah, R., Obeng, N & Kretchy, J. (2010). Seroprevalence of toxoplasmosis among patients visiting the Korle-Bu Teaching Hospital. Accra, Ghana: Reviews in Infection, 1(3),147-150.
Monotoya, J., & Liesenfeld, O. (2004). Toxoplasmosis. Lancet, 363(9425), P1965-1976. https://doi.org/10.1016/S0140-6736(04)16412-X
Desmonts, G., Gouvreur, J., & Congenital. (1974). A Prospective Study of 378 Pregnancies (Vol. 290).New England Journal of Medicine, 290(20),1110-6. https://doi: 10.1056/NEJM197405162902003.
Sasai, M., Pradipta, A & Yamamoto, M. (2018). Host immune responses to Toxoplasma gondii. International Immunology, 30(3), 113-119. https:// doi: 10.1093/intimm/dxy004.
Lima, T.S & Lodoen, M.B. (2019). Mechanisms of Human Innate Immune Evasion by Toxoplasma gondii. Front Cell Infect Microbiol, 9:103.
Khan, I.A., Hwang, S & Moretto, M.(2019). Toxoplasma gondii: CD8 T Cells Cry for CD4 Help. Front Cell Infect Microbiol , 9:136.
Carneiro, A.C., Machado, A.S., Bela, S.R., Costa, J.G., Andrade, G.M., Vasconcelos-Santos, D.V., Januario, J.N., Coelho-Dos-Reis, J.G., Ferro, E.A., TeixeiraCarvalho, A., Vitor, R.W & Martins-Filho, O.A.(2016). Cytokine Signatures Associated With Early Onset, Active Lesions and Late Cicatricial Events of Retinochoroidal Commitment in Infants With Congenital Toxoplasmosis. Journal of Infection Disease, 213 (12), 1962-1970.
Liu, X., Zhao, M., Yang, X., Han, M., Xu, X., Jiang, Y & Hu, X. (2014). Toxoplasma gondii infection of decidual CD1c(+) dendritic cells enhances cytotoxicity of decidual natural killer cells. Inflammation, 37 (4),1261-1270.
Cordeiro, C.A., Moreira, P.R., Andrade, M.S., Dutra, W.O., Campos, W.R., Orefice, F & Teixeira, A.L. (2008). Interleukin-10 gene polymorphism (-1082G/A) is associated with toxoplasmic retinochoroiditis. Invest Ophthalmol Vis Sci, 49 (5), 1979-1982.
Cordeiro, C.A., Moreira, P.R., Bessa, T.F., Costa, G.C., W.O. Dutra, W.R. Campos, F. Orefice, L.H., Young, L.H & Teixeira A.L. (2013). Interleukin-6 gene polymorphism (-174 G/C) is associated with toxoplasmic retinochoroiditis, Acta Ophthalmol. 91 (4) (2013) e311-e314.
W. Wujcicka, Z. Gaj, J. Wilczynski, D. Nowakowska, Contribution of IL6 -174 G>C and IL1B +3954 C>T polymorphisms to congenital infection with Toxoplasma gondii. (2015). Eur J Clin Microbiol Infect Dis, 34 (11), 2287-2294.
Wujcicka, W., Wilczyński, J & Nowakowska, D. (2013). SNPs in tolllike receptor (TLR) genes as new genetic alterations associated with congenital toxoplasmosis? Eur J Clin Microbiol Infect Dis, 32(4),503–511
Naranjo-Galvis, C.A., de-la-Torre, A., Mantilla-Muriel, L.E., Beltrán-Angarita. L., Elcoroaristizabal-Martín, X., McLeod, R., Alliey-Rodriguez, N., Begeman, I.J., López de Mesa, C., Gómez-Marín, J.E & Sepúlveda-Arias, J.C. (2018). Genetic Polymorphisms in Cytokine Genes in Colombian Patients with Ocular Toxoplasmosis. Infect Immun, 86(4):e00597-17. doi: 10.1128/IAI.00597-17.
Rai, H., Colleran, R., Cassese, S., Joner, M., Kastrati, A & Byrne, R.A. (2021). Association of interleukin 6 -174 G/C polymorphism with coronary artery disease and circulating IL-6 levels: a systematic review and meta-analysis. Inflamm Res Dec, 70(10-12), 1075-1087. doi: 10.1007/s00011-021-01505-7.
Mousa, N.M., Jasim, H.M. (2021). Association of IL-1β +3954 G>A and IL-6 -174 G/C polymorphisms in congenital toxoplasmosis. Vacci Monitor, 30(3), 125-132.
Castellucci, L., Menezes. E., Oliveira, J., Magalhaes, A., Guimaraes, L.H., Lessa, M., Ribeiro, S., Reale, J., Noronha, E.F., Wilson, M.E., Duggal, P., Beaty, T.H., Jeronimo, S., Jamieson, S.E., Bales, A., Blackwell, J.M., de Jesus, A.R & Carvalho EM.(2006). IL6 –174 G/C promoter polymorphism influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil. J Infect Dis, 194(4), 519–527.
Schaaf, B., Rupp, J., Müller-Steinhardt, M., Kruse, J., Boehmke, F., Maass, M., Zabel, P & Dalhoff K. (2005). The interleukin-6 -174 promoter polymorphism is associated with extrapulmonary bacterial dissemination in Streptococcus pneumoniae infection. Cytokine, 31(4),324–328.
Terry, C.F., Loukaci, V & Green FR. (2000). Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J Biol Chem, 275(24),18138–18144
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