Antiradical activity of Flavonoids from the fruits of Crataegus meyeri Pojark
DOI:
https://doi.org/10.5281/zenodo.17386759Keywords:
Crataegus meyeri, environment, DPPH, food reserves, medical useAbstract
Hawthorn is an important edible plant belonging to the Rosaceae family and has a wide range of uses in traditional medicine. In the 19th century, tea made from hawthorn flowers and leaves began to be used as a blood purifier, and since the early 20th century, hawthorn fruits and flowers have been recommended as a remedy for heart and vascular diseases. The biological properties, medical and traditional uses of the Crataegus meyeri Pojark. species selected as the research object were investigated, and the antiradical activity of flavonoids from the fruits against the free radical DPPH was investigated. The relationship between the structure of flavonoids and their radical activity was determined. The results obtained show that the radical neutralizing effect of flavonoids directly depends on the substitution feature of free hydroxyl groups in the flavonoid structure. It was revealed that the presence of 3-OH and 3,4-dihydroxy groups in the flavonoid molecule is decisive for the antiradical activity.
References
Akbulut, H. F. (2024). Crataegus monogyna Jacq. and Crataegus laevigata (Poir.) DC.: Evaluation of fruit, seeds, and stem parts of red hawthorn species in terms of phytochemical and antioxidant properties. Food, 49(4), 669–681.
Amanzadeh, Y., Khanavi, M., Khatamsaz, M., Rajabi, A., & Ebrahimi, S. E. S. (2007). High-performance thin-layer chromatographic fingerprints of flavonoids and phenol carboxylic acids for the standardization of Iranian species of the genus Crataegus L. Iranian Journal of Pharmaceutical Sciences, 3, 143–152.
Arslan, R., Bor, Z., Bektaş, N., Meriçli, A. H., & Öztürk, Y. (2011). Antithrombotic effects of the ethanol extract of Crataegus orientalis in the carrageenan-induced mice tail thrombosis model. Thrombosis Research, 127, 210–213.
Bahri-Sahloul, R., Ammar, S., Fredj, R. B., Saguem, S., Grée, S., Trotin, F., & Skhiri, F. H. (2009). Polyphenol contents and antioxidant activities of extracts from flowers of two Crataegus azarolus L. varieties. Pakistan Journal of Biological Sciences, 12, 660–668.
Bengü, A. Ş., Ertem, H. İ., & Akkoyun, M. B. (2023). Determination of some biochemical values of Crataegus orientalis (Eastern hawthorn) fruit obtained from Genc District of Bingöl. Türk Tarım ve Doğa Bilimleri Dergisi, 10(4), 977–983.
Birinci, C., Yaylacı Karahalil, F., Asadov, E., Mammadov, B., & Maharramov, M. (2025). Phenolic composition and antioxidant properties of bee pollens belonging to Drimia spp. and Castanea sativa L. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 31(2).
Ebrahimzadeh, M. A., & Bahramian, F. (2009). Antioxidant activity of Crataegus pentaegyna fruit extract used as traditional medicine in Iran. Pakistan Journal of Biological Sciences, 12, 413–419.
Ekin, S., Bayramoğlu, M., Göktaşoğlu, A., Özgökçe, F., & Kızıltaş, H. (2017). Antioxidant activity of aqueous and ethanol extracts of Crataegus meyeri Pojark leaves and contents of vitamin and trace elements. Journal of the Chilean Chemical Society, 62(4), 3661–3667.
İbrahimov, A. (2021). Genus Crataegus (Rosaceae) in the flora of Nakhchivan Autonomous Republic of Azerbaijan. In Biodiversity, Conservation and Sustainability in Asia: Volume 1 – Prospects and Challenges in West Asia and Caucasus (pp. 527–545). Cham: Springer International Publishing.
İbrahimov, A. M. (2017). The diversity of genus Crataegus L. (Rosaceae) in the Nakhchivan Autonomous Republic (Republic of Azerbaijan). Ukrainian Journal of Ecology, 7(3), 32–42.
İbrahimov, A. M., Talibov, T. H., & Mammadov, T. S. (2018). Crataegus L. (Rosaceae) in the flora of the Nakhchivan Autonomous Republic of Azerbaijan. International Journal of Agriculture Innovations and Research, 6(4), 109–114.
İbrahimov, A. M., Talibov, T. H., & Matsyura, A. V. (2018). The genus Rosa L. (Rosaceae) in the flora of the Nakhchivan Autonomous Republic (Azerbaijan). Acta Biologica Sibirica, 4(4), 95–102.
Karagül, P. (2024). Hawthorn fruit and leaves (Crataegus spp.): A review on the therapeutic potential against hypertension. Journal of Düzce University Ornamental and Medicinal Plants Botanical Garden, 3(2), 1–12.
Kolaylı, S., Asadov, E., Huseynova, A., Rahimova, S., & Kara, Y. (2024). Phenolic composition and antioxidant properties of black mulberry (Morus nigra L.) fruits and leaves. Journal of Wildlife and Biodiversity, 8(2), 355–364.
Kumar, D., Arya, V., Bhat, Z. A., Khan, N. A., & Prasad, D. N. (2012). The genus Crataegus: Chemical and pharmacological perspectives. Revista Brasileira de Farmacognosia, 22, 1187–1200.
Rahimova, S., Asadov, E., & Huseynova, A. (2024). Comparative assessment of antioxidant activity in red apricot (Prunus armeniaca L.) and fig fruits (Ficus carica L.) cultivated in Nakhchivan AR, Azerbaijan. International Journal of Secondary Metabolite, 11(4), 722–728.
Šavikin, K. P., Krstić-Milošević, D. B., Menković, N. R., Beara, I. N., Mrkonjić, Z. O., & Pljevljakušić, D. S. (2017). Crataegus orientalis leaves and berries: Phenolic profiles, antioxidant and anti-inflammatory activity. Natural Product Communications, 12(2), 1934578X1701200204.
Yusuf, J. B., & Meriçli, A. H. (2016). Pharmacological activities of Crataegus species: A review. Heart Failure, 5, 29.
Long, S. R., Carey, R. A., Crofoot, K. M., Proteau, P. J., & Filtz, T. M. (2006). Effect of hawthorn (Crataegus oxyacantha) crude extract and chromatographic fractions on multiple activities in a cultured cardiomyocyte assay. Phytomedicine, 13(9–10), 643–650.
Orhan, I., Özçelik, B., Kartal, M., Özdeveci, B., & Duman, H. (2007). HPLC quantification of vitexin-2″-O-rhamnoside and hyperoside in three Crataegus species and their antimicrobial and antiviral activities. Chromatographia, 66(Suppl. 1), 153–157.