Anti-inflammatory, antipyretic and analgesic activities of ethanol extract of Carica papaya


  • Sobia Alyas The University of Lahore, Lahore, Pakistan
  • Nureen Zahra The University of Lahore, Lahore, Pakistan
  • Muhammad Imtiaz Ahmad The University of Lahore, Lahore, Pakistan
  • Nimra Zahid The University of Lahore, Lahore, Pakistan
  • Ayesha Nisar The University of Lahore, Lahore, Pakistan
  • Muhammad Mansoor Hafeez The University of Lahore, Lahore, Pakistan
  • Rabail Alam The University of Lahore, Lahore, Pakistan
  • Asia Parveen The University of Lahore, Lahore, Pakistan
  • Arif malik The University of Lahore, Lahore, Pakistan



Analgesic, anti-inflammatory, anti-pyretic, Carica papaya L, dicleofenac, paracetamol, stem, leaf


The aim of present study is to evaluate the anti-inflammatory, anti-pyretic and analgesic activities of ethanol extract of Carica papaya L. on albino rats. Plant of C. papaya L. is commonly used to treat different diseases like fever, pain, and inflammation. A total of 144 albino rats with an average weight of 160-200g were used in this study. Rats were divided into 4 groups each group contained 12 rats. Anti-inflammatory activity was evaluated by ‎‎0.1 mL of 1% carrageenan extract that induces paw edema while analgesic activity was investigated by acetic acid that induces abdominal writhing response where antipyretic activity was demonstrated by yeast that induces pyrexia in rats. In anti-inflammatory, antipyretic and analgesic activities, significant results were shown at 400mg/kg, 50mg/kg and 400mg/kg doses respectively in multiple comparisons. The stem extract of C. papaya L. showed significant results as compared to leaf extract in anti-inflammatory and antipyretic activities. The leaf extract of C. papaya showed significant results as compared to the stem in analgesic activity.


Aravind G., Debjit B., Duraivel S., Harish G. 2013. Traditional and

medicinal uses of Carica papaya. Journal of medicinal plant studies1(1): 7-15.

Bairagi S.M., Inayat B.P., Nitin N. 2017. Analgesic and anti-inflammatory activity of crude leaf and bark extract of Lantana Camara. Marmara Pharma Journal 21: 810- 817.

Baslingappa S.S., Nayan S.J.K., Meghatai M.P., Parag M.H. 2012. Jamun (Syzgiumcumini (L)): A review of its food and medicinal uses. Food and nutrition science 3: 1100-1117.

Kifayatullah M., Haroon R., Naeem UJ., Kamran AC., Irfan U., Sudair A. 2019. In vivo Analgesic, Antipyretic and Anti-inflammatory Activities of Ethanol Extract of Pericampylus glaucus in Experimental Animals. International Journal of Sustainable Manufacturing. 48: 639-635.

Mohanvelu R., Sudha MA., Ramabhimaiah S. 2014. Evaluation of the analgesic activity of aqueous extract of Mangifera indica leaves in albino rats.International Journal of Basic Clinical Pharmacol. 4 (1):107-110.

Orhue P.O., Momoh A.R. 2013. Antibacterial activities of different solvent extracts of Carica papaya fruit parts on some gram-positive and gram-negative organisms. International Journal of Herbs and Pharmacological Research 2(4): 42 – 47.

Parra S.A., Kalpesh G., Ashok D., Mohammad I.R. 2019. Evaluation of anti-inflammatory and analgesic activity of methanolic extract of Berberis lyciumRoyle. Journal of Medicinal Plants Studies7: 39-45.

Roshan R., Navneet K.V., Anubha G. 2014. A breif study on Carica papaya. International Journal of Current Trends in Phrmaceutical Research.2(4): 541-550.

Safari V.Z., Kamau J.K., Nthiga P.M., Ngugi M.P., Orinda G., Njagi E.M. 2016. Antipyretic, Anti-inflammatory and Analgesic Activities of Aqueous Leaf Extract of Aloe volkensii in Albino Mice. Medicinal Aromatic Plants 5: 1-7.

Subedi N.K., Rehman A.M.S., Mohammad A.A. 2016. Analgesic and Antipyretic Activities of Methanol Extract and Its Fraction from the Root of Schoenoplectus grossus. Evidence-Based Complementary and Alternative Medicine 1-8.

Sultana T., Kamal U.A., Nazmun N., Shariful I., Shahariar J. 2018. Growth and Yield Response of Some Rice Genotype under Different Duration of Complete Submergence. Journal of Agriculture and Ecology Research International 15(1): 1-11.

Vinod K. 2019. Learning the healthcare system enabled by real-time knowledge extraction from textdata 1-33.

Anjum F., Shazia A., Bukhari M.S., Tanveer H.B., Mir M.T. 2013. Exploration of nutraceuticical potential of herbal oil formulated from prasitic plant. African Journal of Traditional Complement Alternative Medicine 11(1): 78-86.

Jagdish J., Meena A., Rekesh S. 2014. Evaluation of some biopesticides against some important lepidopteron pests of pigeonpea. Greener Journal of Agricultural sciences 4(6): 232-237.




How to Cite

Alyas, S., Zahra, N. ., Ahmad, M. I. ., Zahid, N. ., Nisar, A., Hafeez, M. M., Alam, R., Parveen, A. ., & malik, A. (2020). Anti-inflammatory, antipyretic and analgesic activities of ethanol extract of Carica papaya. Journal of Wildlife and Biodiversity, 4(3), 18–23.