TY - JOUR AU - Alyas, Sobia AU - Zahra, Nureen AU - Ahmad, Muhammad Imtiaz AU - Zahid, Nimra AU - Nisar, Ayesha AU - Hafeez, Muhammad Mansoor AU - Alam, Rabail AU - Parveen, Asia AU - malik, Arif PY - 2020/07/30 Y2 - 2024/03/28 TI - Anti-inflammatory, antipyretic and analgesic activities of ethanol extract of Carica papaya JF - Journal of Wildlife and Biodiversity JA - JWB VL - 4 IS - 3 SE - Original Article DO - 10.22120/jwb.2020.120874.1116 UR - https://wildlife-biodiversity.com/index.php/jwb/article/view/79 SP - 18-23 AB - <p>The aim of present study is to evaluate the anti-inflammatory, anti-pyretic&nbsp;<strong>‎</strong>and analgesic activities of ethanol extract of&nbsp;<em>Carica papaya</em>&nbsp;L. on albino rats.&nbsp;<strong>‎</strong>Plant of&nbsp;<em>C. papaya</em>&nbsp;L. is commonly used to treat&nbsp;<strong>‎</strong>different diseases like fever, pain, and inflammation. A total of 144 albino rats&nbsp;<strong>‎</strong>with an average weight of 160-200g were used in this study. Rats were divided into 4&nbsp;<strong>‎</strong>groups each group contained 12 rats. Anti-inflammatory activity was evaluated by&nbsp;<strong>‎‎</strong>0.1 mL of 1% carrageenan extract that induces paw edema while analgesic activity&nbsp;<strong>‎</strong>was investigated by acetic acid that induces abdominal writhing response where&nbsp;<strong>‎</strong>antipyretic activity was demonstrated by yeast that induces pyrexia in rats.&nbsp;<strong>‎</strong>In anti-inflammatory, antipyretic and analgesic activities, significant&nbsp;<strong>‎</strong>results were shown at 400mg/kg, 50mg/kg and 400mg/kg doses respectively in&nbsp;<strong>‎</strong>multiple comparisons.&nbsp;<strong>‎</strong>The stem extract of&nbsp;<em>C. papaya</em>&nbsp;L. showed significant results as&nbsp;<strong>‎</strong>compared to leaf extract in anti-inflammatory and antipyretic activities. The leaf&nbsp;<strong>‎</strong>extract of C. papaya showed significant results as compared to the stem in analgesic&nbsp;<strong>‎</strong>activity.</p> ER -